Senior Scientist I – Infectious Diseases

Location of role Oxford, UK

Department Infectious Diseases

Key Responsibilities Contribute towards cross functional efforts focussed on applying the ImmTAX platform or other modalities for the development of novel treatments for chronic infections, including HIV and HBV (Yang et al Mol Ther. 2016 Nov; 24,11; Fergusson et al Hepatology 2020 Nov;72,5). The team is involved in multiple stages of the drug discovery and development process, from target discovery all the way to clinical.

Independently or collaboratively plan, design, and execute experimental investigations, enabling the advancement of the Company pipeline, process, or technology capabilities.

Key Responsibilities:

• Independently plan, design and execute projects. Typically conduct more than one project at a time with moderate manager guidance
• Execute experiments to address key scientific questions and enable project progression, utilizing range of techniques including cell culture, flow cytometry, ELISpots, ELISAs, DD-PCR, qPCR, and NextGen sequencing.
• Some work will be conducted in a containment level 3 (CL3 facility) and will require handling of human viruses
• Make detailed observations, analyse data, interpret results, and make recommendations
• Proactively expand scientific/technical knowledge in relevant fields including HIV/HBV functional cure through review of scientific literature/conference updates, peer to peer mentoring, and attendance at seminars/conferences in line with company strategy
• Work effectively in a matrixed team structure and as part of cross functional teams
• Effectively participate and present at internal/external meetings
• Influence scientific thinking and direction of projects and demonstrate some leadership qualities through project team participation, internal consulting and mentoring
• Act as a resource for colleagues with less experience
  
  

Education, Experience and Knowledge:

Essential Qualifications:

• PhD in molecular biology, cell biology, virology, immunology, or related discipline and a minimum of 2-5 years related experience
• Alternatively, a BSc or MSc with significant work experience in relevant scientific areas
• Experience working in Infectious diseases, specifically with HIV
• Worked in a bench-based laboratory environment and proficient in the following key techniques:
• culturing primary cells and cell lines
• flow cytometry, ELISAs, ELISpots
• molecular techniques including some of the following: PCR, Mutagenesis, qPCR, Droplet Digital PCR, NextGen sequencing, Genomics/Transcriptomics
• Experience working in CL3 facilities and in compliance with Human Tissue Authority requirements
• Contributes towards and brings new ideas/knowledge to scientific team discussions
• Experience presenting at internal or external meetings
  
  

Preferred Qualifications:

• Knowledge/expertise of Immunology/HBV/EBV
• Knowledge/expertise of in vitro infection models using viruses
• Supervision/mentoring experience e.g. training junior staff in lab techniques and data interpretation
  
  

About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.