Scientist

United Kingdom, Cambridge

Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

The Role

We are recruiting a Scientist with a background in cell expression technologies to join our R&D Cell Engineering and CLC group at our Cambridge site. This is an outstanding opportunity to be at the forefront of developing next-generation, industrially relevant cell expression platforms.

This is an excellent opportunity to play a key role in advancing expression systems and services for the efficient production of complex therapeutic proteins and contributing to world-class scientific breakthroughs!

Key Responsibilities

• Contribute to the delivery of new CHO-based mammalian expression hosts and vector systems for the expression of complex therapeutic proteins.
• Engineer mammalian cell lines using brand-new techniques like random integration, targeted integration, and gene editing (e.g., CRISPR-based systems).
• Develop mammalian expression vectors using brand-new assembly techniques.
• Perform phenotypic characterisation of edited cell lines with relevant assays (e.g., NGS, ddPCR, qPCR, and flow cytometry) and cell culture techniques (e.g., shake flask/bioreactor).
• Collate, analyse, and evaluate data, ensuring the production of high-quality information and traceable records under the direction of the project lead.
• Present results in written and oral reports.
• Collaborate closely with other R&D groups to deliver improvements in recombinant protein expression, particularly with R&D Process Development, Protein Analytics & Informatics/Data Management.
  
  

Key requirements:

• BSc/MSc Degree in Life Sciences, Molecular Biology, or a related field.
• Practical experience within R&D in industrial or academic settings.
• Strong technical background in molecular biology and cell culture, focusing on developing or manipulating mammalian expression systems (hosts, vectors, and processes).
• Experience with cell line engineering, ideally with CRISPR-based systems. Experience with pooled and/or arrayed CRISPR-based screening is advantageous.
• Familiarity with the implementation and development of automation for cell line screening.
• Experience analysing next-generation sequencing data is advantageous.
• Proven ability to contribute to technology development projects and successfully implement new technologies transferable from research to GMP manufacture.
• Ability to work in cross-functional groups to transfer technology and support commercialisation.
• Proactive attitude towards solving challenging problems.
• Good working knowledge of statistics and expertise in the design of experiments.
  
  

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Reference: R68267

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