PK/PD Modeling / Pharmacometrics Lead
Mercor
Date: 2 weeks ago
City: Remote
Contract type: Full time
Remote
This person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in quantitative structure and parameter plausibility.
Who We’re Looking For
Who We’re Looking For
- Deep hands-on experience in PK, PD, exposure–response modeling, and ideally population PK or QSP.
- Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces.
- Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations.
- Comfortable designing model evaluation rubrics that distinguish between acceptable vs. non-credible outputs.
- Able to articulate how quantitative checks should complement narrative decision logic.
- Experience supporting translational or clinical pharmacology leads in dose justification.
- Familiarity with integrating nonclinical PK/PD data (2-species GLP → human FIH extrapolation).
- :8–12 years of quantitative pharmacology experience in pharma, CROs, or modeling consultancies.
- Strong portfolio in population PK/PD, exposure–response, and parameter estimation using NONMEM, Monolix, or equivalent tools.
- Demonstrated ability to interpret model results for decision-making, not just fit data.
- Can create fit-for-purpose models and critique model structures or assumptions under uncertainty.
- Design and refine micro-evaluations for PK/PD performance (curve fits, parameter checks, error taxonomies).
- Encode quantitative sanity checks into model rubrics for automated evaluation.
- Define failure conditions (e.g., unsafe extrapolation, poor coverage curves, invalid assumptions).
- PK/PD datasets, tox summaries, and performance prompts (e.g., “fit exposure–response curves, interpret safety margins”).
- Example model outputs from automated systems.
- Quantitative Rubrics: clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks.
- Golden Fit Examples: representative “ideal” PK/PD model outputs and visualizations for calibration.
- Error Taxonomy: structured list of typical modeling or fitting errors, with root-cause annotations.
- Meta-Layer Commentary: short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values.
- Contract / part-time, remote, outcome-based deliverables.
How to apply
To apply for this job you need to authorize on our website. If you don't have an account yet, please register.
Post a resumeSimilar jobs
Voice recording (Canadian French Accent, Canada)
Mercor,
Remote
11 hours ago
We are collecting audio accents for a multi-lingual AI platform. We’re collecting :3 hours of phone audio where speakers spell out names, emails, and phone numbers naturally — like talking to customer support. There will be different variations, environments you will need to work with (quietly, muffled voice, Phone on speaker-mode etc.) How it works:You’ll call a demo line and...
Aeronautical Engineering & Maintenance - Scrutineer - Remote
City & Guilds - Associate Recruitment,
Remote
1 week ago
For more information, please see the Role Profiles and Person SpecificationThe assessments within the Aeronautical and Engineering qualifications include Multiple Choice exams. We are looking for examiners to help produce Multiple-Choice questions (MCQ) with ongoing maintenance of the examinations. As part of the recruitment process we will explain more about the requirements and on-going commitments of the roles.We will also...
Travel Consultant
BCD Travel,
Remote
2 weeks ago
Start your journey with BCD: Grow, connect, collaborate and celebrate with our global teamTravel Agent (Remote) Full time, UK or PolandAs a Travel Consultant, you are the face of our company. You’ll communicate and respond to requests for current and new clients, helping them travel smart and achieve more. Do you communicate effortlessly and have customer service at heart? –...
