Senior Scientist (ATDBio)
Biotage
Date: 2 weeks ago
City: Southampton
Contract type: Full time

Senior Scientist – SME Mass Spectrometry
Location: Southampton
Department: Oligonucleotide Production
Join our high-performing Oligonucleotide Production Team in Southampton, where innovation meets excellence. We are seeking a Senior Scientist with deep expertise in Mass Spectrometry to lead analytical strategy and contribute to the development and production of high-quality modified oligonucleotides.
Key Responsibilities
Location: Southampton
Department: Oligonucleotide Production
Join our high-performing Oligonucleotide Production Team in Southampton, where innovation meets excellence. We are seeking a Senior Scientist with deep expertise in Mass Spectrometry to lead analytical strategy and contribute to the development and production of high-quality modified oligonucleotides.
Key Responsibilities
- Lead and oversee analytical workflows involving LC-MS, HPLC, PAGE, UPLC-MS and flash.
- chromatography to support oligonucleotide synthesis and purification.
- Act as the subject matter expert (SME) in Mass Spectrometry, driving method development, troubleshooting, and continuous improvement initiatives
- Collaborate cross-functionally to optimize small molecule preparation and oligonucleotide synthesis processes.
- Maintain and calibrate analytical instrumentation, ensuring high performance and compliance with quality standards.
- Provide technical leadership and mentorship to Associate Scientists and Lab Technicians, supporting training and development.
- Ensure rigorous documentation and data integrity in line with ISO and internal quality systems.
- Champion Health, Safety, and Environmental (HSE) standards and promote a culture of safety and compliance.
- Manage inventory and procurement of analytical reagents and consumables.
- Stay abreast of emerging technologies and methodologies in nucleic acid chemistry and analytical science.
- PhD in Chemistry, Analytical Chemistry, or a related discipline.
- Proven experience in a high-throughput chemistry or oligonucleotide production environment.
- Extensive hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Experience of waters connect is highly desirable)
- Strong background in nucleic acid chemistry and familiarity with purification techniques. Oligonucleotide experience is highly desirable
- Demonstrated ability to lead projects, mentor junior staff, and influence scientific strategy.
- Experience working within ISO or GMP-regulated environments.
- Excellent problem-solving, communication, and organizational skills.
- The successful candidate will be a self-starter with the ability to work under pressure in a fast-changing environment, detail orientated along with strong communication skills.
- 25 days annual leave plus 8 paid bank holidays
- Contributory pension scheme (6% employer contribution)
- Flexible working hours
- Life Assurance (x4 salary)
- Long service awards
- Reward and recognition scheme
- Employer Assistance Programme with 24/7 remote GP service
- Annual flu jabs
- Cycle to work scheme
- Corporate discount on gym membership
- Savings and discounts
- Reimbursement of professional membership fees
- Referral incentives
- Social events
- Volunteering days
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